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    Pheno-menal

    Pheno-menal

    The truth wins out in the end. Time and again we have fallen in love with spectacular molecular techniques of drug discovery, but Mother...
    A tissue a tasket

    A tissue a tasket

    It seems like an obvious concept: Let's say you are developing a drug that works by inhibiting, say, phosphodiesterase-4 (PDE-4) to treat...
    Meh-dicine

    Meh-dicine

    The holy grail of the pharma industry is FDA approval, but the final clue may be positive top-line (Phase III) results. However, it is...
    Shock drop

    Shock drop

    There are drug adverse events, and then there are the Voldemorts of drug adverse effects, whose which-must-not-be-named. Bleeding in...
    Heart breaker

    Heart breaker

    Small molecule chemical antibiotics are among the most prescribed drugs in the world, and few individuals in the first world can say they...
    Grand stranding

    Grand stranding

    Dr. He Jiankui dragged everyone into a brave new world when he edited human embryo genomes to be resistant to HIV and those embryos were...
    It's been a hard day's development

    It's been a hard day's development

    Pharma small molecule discovery has continued its longtime inexorable decline noted some time ago in this paper. There is little doubt...
    Southern hemis-fears

    Southern hemis-fears

    First-in-class drugs are drugs targeting different gene products than have never successfully been targeted before for therapy. ...
    Prediction looks to the future

    Prediction looks to the future

    It’s long been known that better early prediction of drug-like compound properties overcomes costly drug attrition later. But prediction...
    Reading cancer's résumé

    Reading cancer's résumé

    Thinking about battling cancer without understanding its tissue of origin would be like hiring someone without knowing about their...
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