THE GENE

EXPRESS

Sick factor

Fast and spurious

Screen stars

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Pheno-menal

The truth wins out in the end. Time and again we have fallen in love with spectacular molecular techniques of drug discovery, but Mother...

A tissue a tasket

It seems like an obvious concept: Let's say you are developing a drug that works by inhibiting, say, phosphodiesterase-4 (PDE-4) to treat...

Meh-dicine

The holy grail of the pharma industry is FDA approval, but the final clue may be positive top-line (Phase III) results. However, it is n...

Shock drop

There are drug adverse events, and then there are the Voldemorts of drug adverse effects, whose which-must-not-be-named. Bleeding in you...

Heart breaker

Small molecule chemical antibiotics are among the most prescribed drugs in the world, and few individuals in the first world can say they...

Grand stranding

Dr. He Jiankui dragged everyone into a brave new world when he edited human embryo genomes to be resistant to HIV and those embryos were ...

It's been a hard day's development

Pharma small molecule discovery has continued its longtime inexorable decline noted some time ago in this paper. There is little doubt t...

Southern hemis-fears

First-in-class drugs are drugs targeting different gene products than have never successfully been targeted before for therapy. Sometime...

Prediction looks to the future

It’s long been known that better early prediction of drug-like compound properties overcomes costly drug attrition later. But prediction...

Reading cancer's résumé

Thinking about battling cancer without understanding its tissue of origin would be like hiring someone without knowing about their previo...

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