February 24, 2020

The massive inefficiency of target-based high-throughput screening eventually led to major pivots in the pharmaceutical industry. The biggest was to jump the drug-like small molecule ship altogether and develop biologic drugs (drugs that are proteins/antibodies). This...

October 1, 2019

You gotta walk before you can run.  Actually, you usually have to crawl before you walk.  For small molecule drug discovery in the early days, we were talking more about not moving at all from serendipitous discoveries, with maybe a little floundering around in the hop...

May 30, 2019

Medicine was revolutionized in the 20th century by the discovery that inherited human diseases were caused by mutations or variations in individual genes.  Not long after that, molecular biology advanced to the point of routine gene transfer into cells, in no small par...

January 25, 2019

Small molecule chemical antibiotics are among the most prescribed drugs in the world, and few individuals in the first world can say they have never taken at least one course of these drugs.  For a variety of economic reasons, antibiotic drug discovery is increasingly...

October 18, 2018

The pharmaceutical industry has long stayed humble with their rules for successful drug development: "We’re not bigger than the game!" "We will follow rules even if we don’t understand why they work!" Chris Lipinski’s Rule of 5  is a cornerstone, of course, but only ki...

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