April 2, 2020

The early days of the COVID-19 pandemic have seen a rush to repurpose existing approved or near approval drugs, due to the urgency of the viral disease that has no proven treatment. As the SARS-CoV-2 virus causing COVID-19 exhibited in its genome a viral protease (enzy...

February 24, 2020

The massive inefficiency of target-based high-throughput screening eventually led to major pivots in the pharmaceutical industry. The biggest was to jump the drug-like small molecule ship altogether and develop biologic drugs (drugs that are proteins/antibodies). This...

January 28, 2020

Alzheimer’s Disease is an asteroid headed directly at Earth.  An astonishing 1 in 4 Americans are expected to develop this devastating disease during their lifetimes, and its a horror story of a disease, with people losing their ability to even recognize themselves lon...

January 28, 2020

We’ve been through this before. While it may be convenient to refer to Lipitor as an HMG-CoA reductase inhibitor, or aspirin as a cyclooxegenase inhibitor, or Tom Brady as an “athlete,” they are clearly much more than that.  Hence, being too attached to that conception...

January 25, 2019

Martin Karplus of Harvard, Michael Levitt of Stanford and Arieh Warshel of USC were awarded the Nobel Prize in Chemistry in 2013 for thinking “what if we put peanut butter on our chocolate?” Or the super nerd version of that anyway: What if we use COMPUTERS to visualiz...

December 20, 2018

Pharma small molecule discovery has continued its longtime inexorable decline noted some time ago in this paper.  There is little doubt that the bang for the buck is now a desperate wheeze, as the number of drugs obtained per billion dollars spent on drug development h...

December 20, 2018

There is a critical, long-term absence of progress in drug discovery for mental health.  Of the multitude of psychiatric small molecule drugs prescribed in the past century, only two were first-in-class drug discoveries; lithium for the treatment of bipolar disorder in...

October 18, 2018

Some autoimmune diseases, like lupus, affect multiple tissues, but some, like inflammatory bowel disease, affect only specific types.  A new study reveals that HDAC7 controls tissue-specific autoimmunity in othertissues via its action in the thymus, a mechanism which y...

October 18, 2018

The pharmaceutical industry has long stayed humble with their rules for successful drug development: "We’re not bigger than the game!" "We will follow rules even if we don’t understand why they work!" Chris Lipinski’s Rule of 5  is a cornerstone, of course, but only ki...

September 12, 2018

Drug repurposing is seen to be a major growth area in the drug development field because it trades the unsolved problem of attrition for the seemingly solvable problem of finding a new use for an old, already-approved drug.  But maybe that’s not an easier problem?! A r...

Please reload

THE GENE

EXPRESS

Recent News

Sick factor

June 2, 2020

Fast and spurious

June 2, 2020

Screen stars

June 2, 2020

1/4
Please reload

Tags