February 24, 2020

In contrast to target-based strategies, phenotypic drug discovery does not rely on knowledge of a specific drug target or a hypothesis about its role in disease, but instead focuses on finding a gene or small molecule that corrects a cellular characteristic that is spe...

February 24, 2020

The truth wins out in the end.  Time and again we have fallen in love with spectacular molecular techniques of drug discovery, but Mother Nature is about the big picture–biology–which might as well be dark matter for how well we understand and control it.

And so it is w...

October 1, 2019

You gotta walk before you can run.  Actually, you usually have to crawl before you walk.  For small molecule drug discovery in the early days, we were talking more about not moving at all from serendipitous discoveries, with maybe a little floundering around in the hop...

October 18, 2018

The pharmaceutical industry has long stayed humble with their rules for successful drug development: "We’re not bigger than the game!" "We will follow rules even if we don’t understand why they work!" Chris Lipinski’s Rule of 5  is a cornerstone, of course, but only ki...

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