June 2, 2020

Did you ever wonder: Hey, the original SARS outbreak was 15 years ago, why don’t we just use the SARS vaccine we put our (and every opportunistic scientist's) all into developing on COVID-19?  Oh right, there IS no SARS vaccine. Hmmm.  Why is that, exactly?...

January 28, 2020

We’ve been through this before. While it may be convenient to refer to Lipitor as an HMG-CoA reductase inhibitor, or aspirin as a cyclooxegenase inhibitor, or Tom Brady as an “athlete,” they are clearly much more than that.  Hence, being too attached to that conception...

March 21, 2019

“Only one person in human history has ever been cured from HIV infection by medical intervention. Wait . . ." *listens to earpiece* "What’s that? OK, well–correction!" That old line won’t work anymore: As of this month, there is a SECOND person who appears to have been...

March 21, 2019

There are drug adverse events, and then there are the Voldemortsof drug adverse effects, whose which-must-not-be-named.  Bleeding in your stomach lining is one. Basically, you can lose half of your blood volume before the blood appears at the “exit point” alerting you...

February 28, 2019

Ken Kesey captured what is so frustrating about both schizophrenia and the primitive mental health system that is charged with treating it.  The disease is characterized most visibly by “psychosis,” which is itself poorly defined, but generally means a break with reali...

January 25, 2019

Imagine you have discovered a hit compound to treat drug addiction.  Before you drop $1 billion on its development, wouldn’t you want to handicap the odds of its success as best you can?  As we well know we do this poorly, but as the age of machine learning has ta...

January 25, 2019

Martin Karplus of Harvard, Michael Levitt of Stanford and Arieh Warshel of USC were awarded the Nobel Prize in Chemistry in 2013 for thinking “what if we put peanut butter on our chocolate?” Or the super nerd version of that anyway: What if we use COMPUTERS to visualiz...

December 20, 2018

There is a critical, long-term absence of progress in drug discovery for mental health.  Of the multitude of psychiatric small molecule drugs prescribed in the past century, only two were first-in-class drug discoveries; lithium for the treatment of bipolar disorder in...

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