January 25, 2019

Small molecule chemical antibiotics are among the most prescribed drugs in the world, and few individuals in the first world can say they have never taken at least one course of these drugs.  For a variety of economic reasons, antibiotic drug discovery is increasingly...

January 25, 2019

Martin Karplus of Harvard, Michael Levitt of Stanford and Arieh Warshel of USC were awarded the Nobel Prize in Chemistry in 2013 for thinking “what if we put peanut butter on our chocolate?” Or the super nerd version of that anyway: What if we use COMPUTERS to visualiz...

December 20, 2018

Pharma small molecule discovery has continued its longtime inexorable decline noted some time ago in this paper.  There is little doubt that the bang for the buck is now a desperate wheeze, as the number of drugs obtained per billion dollars spent on drug development h...

October 18, 2018

The pharmaceutical industry has long stayed humble with their rules for successful drug development: "We’re not bigger than the game!" "We will follow rules even if we don’t understand why they work!" Chris Lipinski’s Rule of 5  is a cornerstone, of course, but only ki...

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