February 24, 2020

In contrast to target-based strategies, phenotypic drug discovery does not rely on knowledge of a specific drug target or a hypothesis about its role in disease, but instead focuses on finding a gene or small molecule that corrects a cellular characteristic that is spe...

January 28, 2020

Imagine you had a drug that dramatically improved the symptoms or signs of a disease in 70% of the patients who take it, but carried the risk of stroke or death in 1 out of 1000 people taking it.  Would you approve it for general consumption?

Atrial fibrillation is...

October 30, 2019

It seems like an obvious concept: Let's say you are developing a drug that works by inhibiting, say, phosphodiesterase-4 (PDE-4) to treat depression (fictional). You have collected immense molecular, cellular, animal and clinical data supporting and validating PDE-4 as...

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