June 2, 2020

The SARS-CoV-2 coronavirus that causes COVID-19 disease is an enveloped virus. Meaning, it is mostly human plasma membrane, with a few viral protein units spiking through as points of attachment of the virus to human cells prior to fusing with them and causing infectio...

April 2, 2020

The early days of the COVID-19 pandemic have seen a rush to repurpose existing approved or near approval drugs, due to the urgency of the viral disease that has no proven treatment. As the SARS-CoV-2 virus causing COVID-19 exhibited in its genome a viral protease (enzy...

February 24, 2020

In contrast to target-based strategies, phenotypic drug discovery does not rely on knowledge of a specific drug target or a hypothesis about its role in disease, but instead focuses on finding a gene or small molecule that corrects a cellular characteristic that is spe...

February 24, 2020

The truth wins out in the end.  Time and again we have fallen in love with spectacular molecular techniques of drug discovery, but Mother Nature is about the big picture–biology–which might as well be dark matter for how well we understand and control it.

And so it is w...

January 28, 2020

We’ve been through this before. While it may be convenient to refer to Lipitor as an HMG-CoA reductase inhibitor, or aspirin as a cyclooxegenase inhibitor, or Tom Brady as an “athlete,” they are clearly much more than that.  Hence, being too attached to that conception...

October 30, 2019

Despite anatomy being the first topic to challenge the student in medical school for over 150 years, attention to variation of drug targets across tissues in the human body has remained scant even to the present day. GeneCentrix has pioneered the incorporation of trans...

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