April 2, 2020

While the protease inhibitor flopped for COVID-19, that doesn’t mean that the line of reasoning of drugs cross-reactive with viral enzymes is a non-starter. Indeed, long ago, the drug AZT that mimicked a sub-component of the nucleotides that make up DNA was developed t...

February 24, 2020

The massive inefficiency of target-based high-throughput screening eventually led to major pivots in the pharmaceutical industry. The biggest was to jump the drug-like small molecule ship altogether and develop biologic drugs (drugs that are proteins/antibodies). This...

February 24, 2020

In contrast to target-based strategies, phenotypic drug discovery does not rely on knowledge of a specific drug target or a hypothesis about its role in disease, but instead focuses on finding a gene or small molecule that corrects a cellular characteristic that is spe...

January 28, 2020

Alzheimer’s Disease is an asteroid headed directly at Earth.  An astonishing 1 in 4 Americans are expected to develop this devastating disease during their lifetimes, and its a horror story of a disease, with people losing their ability to even recognize themselves lon...

October 30, 2019

Despite anatomy being the first topic to challenge the student in medical school for over 150 years, attention to variation of drug targets across tissues in the human body has remained scant even to the present day. GeneCentrix has pioneered the incorporation of trans...

October 1, 2019

You gotta walk before you can run.  Actually, you usually have to crawl before you walk.  For small molecule drug discovery in the early days, we were talking more about not moving at all from serendipitous discoveries, with maybe a little floundering around in the hop...

July 26, 2019

Mankind would be nowhere without respect for the fundamentals.  And search might be the most fundamental process of all.  Faster ways to find information might sound boring, but we literally use those advances every second.  Remember the phone book? (Shudder) We rememb...

May 30, 2019

The story begins in the 1950s when thalidomide was approved as an over the counter sedative in Europe, but conspicuously rejected by the FDA in the US.  Shortly thereafter, it was discovered that thousands of babies were born without limbs or shortened limbs, a conditi...

April 30, 2019

In any competitive sport, you know that what worked one time down the field/floor/ice is VERY unlikely to work again the second time.  We would use that principle to adjust the truism that “past success is no guarantee of future performance” to “past success is LIKELY...

March 21, 2019

“Only one person in human history has ever been cured from HIV infection by medical intervention. Wait . . ." *listens to earpiece* "What’s that? OK, well–correction!" That old line won’t work anymore: As of this month, there is a SECOND person who appears to have been...

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