April 2, 2020

While the protease inhibitor flopped for COVID-19, that doesn’t mean that the line of reasoning of drugs cross-reactive with viral enzymes is a non-starter. Indeed, long ago, the drug AZT that mimicked a sub-component of the nucleotides that make up DNA was developed t...

February 24, 2020

The massive inefficiency of target-based high-throughput screening eventually led to major pivots in the pharmaceutical industry. The biggest was to jump the drug-like small molecule ship altogether and develop biologic drugs (drugs that are proteins/antibodies). This...

February 24, 2020

In contrast to target-based strategies, phenotypic drug discovery does not rely on knowledge of a specific drug target or a hypothesis about its role in disease, but instead focuses on finding a gene or small molecule that corrects a cellular characteristic that is spe...

February 24, 2020

The truth wins out in the end.  Time and again we have fallen in love with spectacular molecular techniques of drug discovery, but Mother Nature is about the big picture–biology–which might as well be dark matter for how well we understand and control it.

And so it is w...

January 28, 2020

Alzheimer’s Disease is an asteroid headed directly at Earth.  An astonishing 1 in 4 Americans are expected to develop this devastating disease during their lifetimes, and its a horror story of a disease, with people losing their ability to even recognize themselves lon...

January 28, 2020

We’ve been through this before. While it may be convenient to refer to Lipitor as an HMG-CoA reductase inhibitor, or aspirin as a cyclooxegenase inhibitor, or Tom Brady as an “athlete,” they are clearly much more than that.  Hence, being too attached to that conception...

October 30, 2019

Despite anatomy being the first topic to challenge the student in medical school for over 150 years, attention to variation of drug targets across tissues in the human body has remained scant even to the present day. GeneCentrix has pioneered the incorporation of trans...

July 26, 2019

Mankind would be nowhere without respect for the fundamentals.  And search might be the most fundamental process of all.  Faster ways to find information might sound boring, but we literally use those advances every second.  Remember the phone book? (Shudder) We rememb...

April 30, 2019

In the 1980’s, shortly after the HIV virus was isolated as the cause of the terrifying unexplained disease AIDS, Ronald Reagan’s Health and Human Services secretary famously suggested that a vaccine would be available within two years.  Fast forward 30 years and we are...

April 30, 2019

In any competitive sport, you know that what worked one time down the field/floor/ice is VERY unlikely to work again the second time.  We would use that principle to adjust the truism that “past success is no guarantee of future performance” to “past success is LIKELY...

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