February 24, 2020

The truth wins out in the end.  Time and again we have fallen in love with spectacular molecular techniques of drug discovery, but Mother Nature is about the big picture–biology–which might as well be dark matter for how well we understand and control it.

And so it is w...

January 28, 2020

Alzheimer’s Disease is an asteroid headed directly at Earth.  An astonishing 1 in 4 Americans are expected to develop this devastating disease during their lifetimes, and its a horror story of a disease, with people losing their ability to even recognize themselves lon...

March 21, 2019

There are drug adverse events, and then there are the Voldemortsof drug adverse effects, whose which-must-not-be-named.  Bleeding in your stomach lining is one. Basically, you can lose half of your blood volume before the blood appears at the “exit point” alerting you...

February 28, 2019

Context counts.  If you are running towards the scene of a crime, you are doing something and you ARE something VERY different than if you are running away from the scene of a crime.  It's exactly the same thing: running, but the context makes the phenotype completely...

October 18, 2018

Thinking about battling cancer without understanding its tissue of origin would be like hiring someone without knowing about their previous employment.  This vintage book review organizes some great, old thoughts on tissue specificity for anti-cancer drug developm...

October 18, 2018

Clinical holds are lost battles in the war against drug attrition.  The process of drug development critically revolves around the FDA’s Investigational New Drug (IND) application, which is the document required to start testing the drug in humans.  Any safety, efficac...

October 18, 2018

Some autoimmune diseases, like lupus, affect multiple tissues, but some, like inflammatory bowel disease, affect only specific types.  A new study reveals that HDAC7 controls tissue-specific autoimmunity in othertissues via its action in the thymus, a mechanism which y...

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