January 28, 2020

Alzheimer’s Disease is an asteroid headed directly at Earth.  An astonishing 1 in 4 Americans are expected to develop this devastating disease during their lifetimes, and its a horror story of a disease, with people losing their ability to even recognize themselves lon...

March 21, 2019

This one comes out of the past, but it is about a fear as old as time . . . or at least as old as Merck, namely that testing in animals does little to predict efficacy or safety in humans.  Actually, check that. It is actually the rule rather than the exception: Testin...

December 20, 2018

Dr. He Jiankui dragged everyone into a brave new world when he edited human embryo genomes to be resistant to HIV and those embryos were implanted and carried to term birth of twin girls.  This was about as big an explosion in science as has ever occurred.

The news drow...

September 12, 2018

Drug repurposing is seen to be a major growth area in the drug development field because it trades the unsolved problem of attrition for the seemingly solvable problem of finding a new use for an old, already-approved drug.  But maybe that’s not an easier problem?! A r...

September 12, 2018

 Roche and PTC’s Spinal Muscular Atrophy clinical drug trials were waylaid by an unexpected tissue specific effect. After the trial had already started (and 100s of millions of dollars already spent), an unexpected activity was found in the eyes (retinas) of monkeys on...

September 5, 2018

Rare variations in genomic data have long been the bugaboo of computational biologists, those soldiers at the forefront of personalized medicine. These needle-in-the-haystack mutations are nearly impossible to detect by traditional data science approaches (genomics, GW...

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