March 21, 2019

“Only one person in human history has ever been cured from HIV infection by medical intervention. Wait . . ." *listens to earpiece* "What’s that? OK, well–correction!" That old line won’t work anymore: As of this month, there is a SECOND person who appears to have been...

January 25, 2019

Imagine you have discovered a hit compound to treat drug addiction.  Before you drop $1 billion on its development, wouldn’t you want to handicap the odds of its success as best you can?  As we well know we do this poorly, but as the age of machine learning has ta...

January 25, 2019

Small molecule chemical antibiotics are among the most prescribed drugs in the world, and few individuals in the first world can say they have never taken at least one course of these drugs.  For a variety of economic reasons, antibiotic drug discovery is increasingly...

December 20, 2018

Dr. He Jiankui dragged everyone into a brave new world when he edited human embryo genomes to be resistant to HIV and those embryos were implanted and carried to term birth of twin girls.  This was about as big an explosion in science as has ever occurred.

The news drow...

December 20, 2018

First-in-class drugs are drugs targeting different gene products than have never successfully been targeted before for therapy.  Sometimes it's because the drug target was not recognized as important until recently. Other times it's because the target is notoriously di...

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