May 30, 2019

Medicine was revolutionized in the 20th century by the discovery that inherited human diseases were caused by mutations or variations in individual genes.  Not long after that, molecular biology advanced to the point of routine gene transfer into cells, in no small par...

September 5, 2018

Everyone knows that off-targets are the bane of a drug developers existence, but surprisingly little has been done to address the problem. Nature’s paper from the time machine, “Reducing safety-related drug attrition: the use of in vitro pharmacological profiling,” des...

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