November 20, 2018

It’s long been known that better early prediction of drug-like compound properties overcomes costly drug attrition later.  But prediction is stuck in the dark ages.  In this essay from the last decade, Dr. Malcolm Young entertainingly likens the potentia...

October 18, 2018

Some autoimmune diseases, like lupus, affect multiple tissues, but some, like inflammatory bowel disease, affect only specific types.  A new study reveals that HDAC7 controls tissue-specific autoimmunity in othertissues via its action in the thymus, a mechanism which y...

September 5, 2018

Everyone knows that off-targets are the bane of a drug developers existence, but surprisingly little has been done to address the problem. Nature’s paper from the time machine, “Reducing safety-related drug attrition: the use of in vitro pharmacological profiling,” des...

September 5, 2018

Rare variations in genomic data have long been the bugaboo of computational biologists, those soldiers at the forefront of personalized medicine. These needle-in-the-haystack mutations are nearly impossible to detect by traditional data science approaches (genomics, GW...

August 29, 2018

The overlap between seasonal allergies, asthma and eczema has long been recognized. All three are treated by antihistamines, for example, and their histologies match as well, with eosinophils (a type of white blood cell) migrating from the blood into the skin (eczema),...

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