December 20, 2018

Pharma small molecule discovery has continued its longtime inexorable decline noted some time ago in this paper.  There is little doubt that the bang for the buck is now a desperate wheeze, as the number of drugs obtained per billion dollars spent on drug development h...

November 20, 2018

It’s long been known that better early prediction of drug-like compound properties overcomes costly drug attrition later.  But prediction is stuck in the dark ages.  In this essay from the last decade, Dr. Malcolm Young entertainingly likens the potentia...

September 5, 2018

Everyone knows that off-targets are the bane of a drug developers existence, but surprisingly little has been done to address the problem. Nature’s paper from the time machine, “Reducing safety-related drug attrition: the use of in vitro pharmacological profiling,” des...

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