top of page
Mind matters
Ken Kesey captured what is so frustrating about both schizophrenia and the primitive mental health system that is charged with treating...
At tissue
Context counts. If you are running towards the scene of a crime, you are doing something and you ARE something VERY different than if...
Data with destiny
Imagine you have discovered a hit compound to treat drug addiction. Before you drop $1 billion on its development, wouldn’t you want to...
Heart breaker
Small molecule chemical antibiotics are among the most prescribed drugs in the world, and few individuals in the first world can say they...
Model mayhem
Martin Karplus of Harvard, Michael Levitt of Stanford and Arieh Warshel of USC were awarded the Nobel Prize in Chemistry in 2013 for...
Grand stranding
Dr. He Jiankui dragged everyone into a brave new world when he edited human embryo genomes to be resistant to HIV and those embryos were...
It's been a hard day's development
Pharma small molecule discovery has continued its longtime inexorable decline noted some time ago in this paper. There is little doubt...
Class backwards
There is a critical, long-term absence of progress in drug discovery for mental health. Of the multitude of psychiatric small molecule...
Southern hemis-fears
First-in-class drugs are drugs targeting different gene products than have never successfully been targeted before for therapy. ...
Late doomers
Understanding drug attrition is worth billions. Essentially, every Phase III trial is worth at least 1 billion dollars, taking into...
Blog: Blog
bottom of page