In contrast to target-based strategies, phenotypic drug discovery does not rely on knowledge of a specific drug target or a hypothesis...

The truth wins out in the end. Time and again we have fallen in love with spectacular molecular techniques of drug discovery, but Mother...

Alzheimer’s Disease is an asteroid headed directly at Earth. An astonishing 1 in 4 Americans are expected to develop this devastating...

Imagine you had a drug that dramatically improved the symptoms or signs of a disease in 70% of the patients who take it, but carried the...

We’ve been through this before. While it may be convenient to refer to Lipitor as an HMG-CoA reductase inhibitor, or aspirin as a...

Despite anatomy being the first topic to challenge the student in medical school for over 150 years, attention to variation of drug...

It seems like an obvious concept: Let's say you are developing a drug that works by inhibiting, say, phosphodiesterase-4 (PDE-4) to treat...

Artificial intelligence (AI) conjures up images of Terminators and human enslavement to machines, but, in fact, AI is already a huge and...

After the euphoria of the discovery of the viral cause of AIDS (1984) came the growing (e.g. Dallas Buyer’s Club) desperation as that...

You gotta walk before you can run. Actually, you usually have to crawl before you walk. For small molecule drug discovery in the early...