THE GENE

EXPRESS

Sick factor

Fast and spurious

Screen stars

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Surface charm

A small pilot study from France showed that all six COVID-19 patients given a hydroxychloroquine/azithromycin combination recovered quick...

Auld ligands syne

The massive inefficiency of target-based high-throughput screening eventually led to major pivots in the pharmaceutical industry. The big...

Swede success

Despite anatomy being the first topic to challenge the student in medical school for over 150 years, attention to variation of drug targe...

Frag rocks

You gotta walk before you can run. Actually, you usually have to crawl before you walk. For small molecule drug discovery in the early ...

Screen saviors

High-throughput screening (HTS) has been a blessing and a curse. A blessing in codifying a straightforward approach to discovering drug ...

Leper known

The story begins in the 1950s when thalidomide was approved as an over the counter sedative in Europe, but conspicuously rejected by the ...

Vax populi

In the 1980’s, shortly after the HIV virus was isolated as the cause of the terrifying unexplained disease AIDS, Ronald Reagan’s Health a...

Dr. Knowlittle

This one comes out of the past, but it is about a fear as old as time . . . or at least as old as Merck, namely that testing in animals d...

Data with destiny

Imagine you have discovered a hit compound to treat drug addiction. Before you drop $1 billion on its development, wouldn’t you want to ...

It's been a hard day's development

Pharma small molecule discovery has continued its longtime inexorable decline noted some time ago in this paper. There is little doubt t...

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