THE GENE

EXPRESS

Sick factor

Fast and spurious

Screen stars

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Sick factor

The SARS-CoV-2 coronavirus that causes COVID-19 disease is an enveloped virus. Meaning, it is mostly human plasma membrane, with a few vi...

Fast and spurious

Did you ever wonder: Hey, the original SARS outbreak was 15 years ago, why don’t we just use the SARS vaccine we put our (and every oppor...

Screen stars

Necessity is said to be the mother of invention, but the jury is still out on the success of the desperate and rushed phenotypic screens ...

Nucleic freeze

While the protease inhibitor flopped for COVID-19, that doesn’t mean that the line of reasoning of drugs cross-reactive with viral enzyme...

Surface charm

A small pilot study from France showed that all six COVID-19 patients given a hydroxychloroquine/azithromycin combination recovered quick...

Target practice

The early days of the COVID-19 pandemic have seen a rush to repurpose existing approved or near approval drugs, due to the urgency of the...

Auld ligands syne

The massive inefficiency of target-based high-throughput screening eventually led to major pivots in the pharmaceutical industry. The big...

Screen scene

In contrast to target-based strategies, phenotypic drug discovery does not rely on knowledge of a specific drug target or a hypothesis ab...

Pheno-menal

The truth wins out in the end. Time and again we have fallen in love with spectacular molecular techniques of drug discovery, but Mother...

Back to plaque

Alzheimer’s Disease is an asteroid headed directly at Earth. An astonishing 1 in 4 Americans are expected to develop this devastating di...

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