• What is the Historeceptomics Profiler?

    The Historeceptomics Profiler (HR Profiler) is a drug discovery informatics tool pioneered by Dr. Timothy Cardozo at NYU School of Medicine (Shmelkov et al., 2015). Historeceptomics is a visualization of how the anatomic tissue map (“histo”) of a drug's ensemble of target receptors (“recept”) provides new insights in a drug’s mechanism of action, both for beneficial and adverse phenotypes elicted by the drug. Specifically, many investigators overlook the fact that, in order for a drug to be effective against a disease, it must target proteins expressed in tissues related to the disease (Kumar et al., 2016). Our HR Profiler returns this information and can take any drug-like compound and determine its historeceptomic profile, the list of target-tissue pairs affected by the drug. An illustrative use case of this method to analyze antipsychotic drugs was recently published (Cardozo et al., 2017). Importantly, the current technology is quite specific, but not very sensitive yet.

  • Who is GeneCentrix?

    GeneCentrix was founded in 2015 by Dr. Timothy Cardozo and his team and spun out of New York University to develop commercial products using the historeceptomics method.

  • Who are GeneCentrix's partners and sponsors?

    The R&D of GeneCentrix is funded by the National Institute of General Medical Sciences and the National Library of Medicine of the National Institutes of Health to develop informatics products to predict drug activity in humans. New York University is an equity partner in GeneCentrix. 

  • What bioactivity data do you use? What docking data do you use?

    We currently use Ki, Kd, and IC50 data for human proteins from ChEMBL and DrugBank for our bioactivity data. We are working on a product that will allow users to upload their own bioactivity data as well, stay tuned for updates. For docking data, we have a proprietary database of docking results that grows daily and currently includes over 1700 drugs docked against 6500 proteins, with over 352,000 hits.

  • What is an HR score?

    The historeceptomics (HR) score allows ranking of all human target-tissue pairs for a given drug. It combines the affinity of the drug for the protein target, and the expression level of that target in the tissue. Thus, the HR score is always calculated for a target-tissue pair. A statistical cutoff for significance may be imposed on the ranking/scores. In the current version of the product, only target-tissue pairs with an HR score with p-value<0.01 are diplayed, though all the calculated target-tissue pairs and their scores can be downloaded.

  • How safe are my data?

    The HR Profiler site uses an SSL conncection to our server. We do not store the SMILES strings that are searched, so once the user closes or leaves the page, the data cannot be accessed again.

  • Who can see what structures I upload?

    We do not save the structures that have been searched, so you are the only one who sees the search.

  • What future features will there be?

    In future versions of our profile, we will be incorporating new datasources, such as expression data from cell lines, disease expression data, and brain-specific tissue expression data. Further down the line, we will take other ideas into account: proteomics and protein expression, metabolic data, pharmacokinetics and tissue distribution of the drug. Incorporating these new features will improve performance of our profiler.

  • Can I get a free trial?

    Why, yes. For a limited time, we are offering a free trial for one user for one week. If you are interested in trying out our platform, please go here.

  • Anything else?

    Feel free to contact us and we will get back to you shortly. More detailed information about Historeceptomics is available on the platform, so sign up or try free now!

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