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Pheno-menal
The truth wins out in the end. Time and again we have fallen in love with spectacular molecular techniques of drug discovery, but Mother...
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A tissue a tasket
It seems like an obvious concept: Let's say you are developing a drug that works by inhibiting, say, phosphodiesterase-4 (PDE-4) to treat...
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Meh-dicine
The holy grail of the pharma industry is FDA approval, but the final clue may be positive top-line (Phase III) results. However, it is...
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Shock drop
There are drug adverse events, and then there are the Voldemorts of drug adverse effects, whose which-must-not-be-named. Bleeding in...
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Heart breaker
Small molecule chemical antibiotics are among the most prescribed drugs in the world, and few individuals in the first world can say they...
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Grand stranding
Dr. He Jiankui dragged everyone into a brave new world when he edited human embryo genomes to be resistant to HIV and those embryos were...
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It's been a hard day's development
Pharma small molecule discovery has continued its longtime inexorable decline noted some time ago in this paper. There is little doubt...
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Southern hemis-fears
First-in-class drugs are drugs targeting different gene products than have never successfully been targeted before for therapy. ...
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Prediction looks to the future
It’s long been known that better early prediction of drug-like compound properties overcomes costly drug attrition later. But prediction...
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Reading cancer's résumé
Thinking about battling cancer without understanding its tissue of origin would be like hiring someone without knowing about their...
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