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Screen stars
Necessity is said to be the mother of invention, but the jury is still out on the success of the desperate and rushed phenotypic screens...


Nucleic freeze
While the protease inhibitor flopped for COVID-19, that doesn’t mean that the line of reasoning of drugs cross-reactive with viral...


Screen scene
In contrast to target-based strategies, phenotypic drug discovery does not rely on knowledge of a specific drug target or a hypothesis...


Back to plaque
Alzheimer’s Disease is an asteroid headed directly at Earth. An astonishing 1 in 4 Americans are expected to develop this devastating...


Spice of life
The spice turmeric has long been touted as having magical medical properties. From cancer to rheumatism, the ancients swore by it, and a...


Gene come true
Medicine was revolutionized in the 20th century by the discovery that inherited human diseases were caused by mutations or variations in...


Grand stranding
Dr. He Jiankui dragged everyone into a brave new world when he edited human embryo genomes to be resistant to HIV and those embryos were...

Late doomers
Understanding drug attrition is worth billions. Essentially, every Phase III trial is worth at least 1 billion dollars, taking into...

Searching seizures
While most adverse phenotypes emerging in vivo late in drug development are unpredictable, progress has slowly but surely been made in...

New rules!
The pharmaceutical industry has long stayed humble with their rules for successful drug development: "We’re not bigger than the game!"...
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