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Screen stars
Necessity is said to be the mother of invention, but the jury is still out on the success of the desperate and rushed phenotypic screens...
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Nucleic freeze
While the protease inhibitor flopped for COVID-19, that doesn’t mean that the line of reasoning of drugs cross-reactive with viral...
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Screen scene
In contrast to target-based strategies, phenotypic drug discovery does not rely on knowledge of a specific drug target or a hypothesis...
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Back to plaque
Alzheimer’s Disease is an asteroid headed directly at Earth. An astonishing 1 in 4 Americans are expected to develop this devastating...
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Spice of life
The spice turmeric has long been touted as having magical medical properties. From cancer to rheumatism, the ancients swore by it, and a...
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Gene come true
Medicine was revolutionized in the 20th century by the discovery that inherited human diseases were caused by mutations or variations in...
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Grand stranding
Dr. He Jiankui dragged everyone into a brave new world when he edited human embryo genomes to be resistant to HIV and those embryos were...
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Late doomers
Understanding drug attrition is worth billions. Essentially, every Phase III trial is worth at least 1 billion dollars, taking into...
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Searching seizures
While most adverse phenotypes emerging in vivo late in drug development are unpredictable, progress has slowly but surely been made in...
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New rules!
The pharmaceutical industry has long stayed humble with their rules for successful drug development: "We’re not bigger than the game!"...
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