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Sick factor
The SARS-CoV-2 coronavirus that causes COVID-19 disease is an enveloped virus. Meaning, it is mostly human plasma membrane, with a few...


Pheno-menal
The truth wins out in the end. Time and again we have fallen in love with spectacular molecular techniques of drug discovery, but Mother...


Cracking polypharma
We’ve been through this before. While it may be convenient to refer to Lipitor as an HMG-CoA reductase inhibitor, or aspirin as a...


Metal ahead
Artificial intelligence (AI) conjures up images of Terminators and human enslavement to machines, but, in fact, AI is already a huge and...

Compound problem
Where to even begin? A mold flew in through the window and, presto, penicillin. Hey, then, why not screen all the compounds we have on...


ANA now AMA
The most satisfying solutions are for the longest-standing mysteries. Fermat’s Theorem. Amelia Earhart’s fate. The Golden State Killer....

Mind matters
Ken Kesey captured what is so frustrating about both schizophrenia and the primitive mental health system that is charged with treating...

At tissue
Context counts. If you are running towards the scene of a crime, you are doing something and you ARE something VERY different than if...


Model mayhem
Martin Karplus of Harvard, Michael Levitt of Stanford and Arieh Warshel of USC were awarded the Nobel Prize in Chemistry in 2013 for...

Class backwards
There is a critical, long-term absence of progress in drug discovery for mental health. Of the multitude of psychiatric small molecule...
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